Edited by: Karen Young Kreeger
F.J. de Sauvage, P.E. Haas, S.D. Spencer, B.E. Malloy, A.L. Gurney, S.A. Spencer, W.C. Darbonne, W.J. Henzel, S.C. Wong, W.-J. Kuang, K.J. Oles, B. Hultgren, L.A. Solberg, Jr., D.V. Goeddel, D.L. Eaton, "Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand," Nature, 369:533-8, 1994. (Cited in 102 publications through September 1995)
Comments by Dan L. Eaton, Genentech Inc., South San Francisco, Calif.
This paper describes the purification, cloning, amino acid sequence, and biological activity of a thrombopoietin-like protein. "For over three decades, people have been trying to identify the growth factor [protein] that regulates megakaryocytopoiesis, or blood platelet production," remarks Dan L. Eaton, senior scientist at Genentech Inc., a biotech firm in South San Francisco, Calif. "It's been quite a journey."
SOUGHT AND FOUND Genetech scientists Frederick de Sauvage, left and Dan Eaton were part of a team that cloned and identified the intensely sought-after...