M.B. Kastan, Q. Zhan, W.S. El-Diery, F. Carrier, T. Jacks, W.V. Walsh, B.S. Plunkett, B. Vogelstein, A.J. Fornace, Jr., "A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia," Cell, 71:587-97, 1992. (Total citations through October 1994: 246)
This paper is one of a number of publications from the laboratory of Michael Kastan at the Johns Hopkins Oncology Center in Baltimore that describe various steps of a signal-transduction pathway in mammalian cells. It follows up an earlier paper by Kastan's group (M.B. Kastan et al., Cancer Research, 51:6304-11, 1991) that was also identified by The Scientist as a "hot paper" (Sept. 20, 1993, page 16).

"We had previously demonstrated that the p53 gene product--the most commonly mutated gene in human cancer--controls cell-cycle arrest in response to damage," says Kastan. In this paper the authors have identified two new participants in the damage-response pathway, using cells...

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