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Cell Biology

S. Shirodkar, M. Ewen, J.A. DeCaprio, J. Morgan, D.M. Livingston, T. Chittenden, "The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner," Cell, 68:157- 66, 1992. Thomas Chittenden (Immunogen Inc., Cambridge, Mass.): "This work was done in the lab of David M. Livingston at the Dana- Farber Cancer Institute in Boston. The retinoblastoma protein (Rb) belongs to a class of growth regulatory proteins, termed tumor suppre

The Scientist Staff
S. Shirodkar, M. Ewen, J.A. DeCaprio, J. Morgan, D.M. Livingston, T. Chittenden, "The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner," Cell, 68:157- 66, 1992.

Thomas Chittenden (Immunogen Inc., Cambridge, Mass.): "This work was done in the lab of David M. Livingston at the Dana- Farber Cancer Institute in Boston. The retinoblastoma protein (Rb) belongs to a class of growth regulatory proteins, termed tumor suppressors, which function to prevent tumorigenesis. Livingston's laboratory has been interested in understanding, at a molecular level, how Rb negatively regulates cell growth. In 1991 several groups, including our own, demonstrated that Rb forms a complex with the cellular transcription factor E2F. E2F contributes to the cell cycle-dependent transcription of a multitude of genes involved in DNA synthesis and cell proliferation.

"This work is an effort to understand how the activity of E2F is coordinated with...

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