Edited by: Thomas W. Durso and Karen Young Kreeger
S.M. Frisch, H. Francis, "Disruption of epithelial cell-matrix interactions induces apoptosis," Journal of Cell Biology, 124:619-26, 1994. (Cited in nearly 145 publications through August 1996)
CHEATING CELL DEATH : Understanding a form of apoptosis called anoikis may lead to better cancer treatments, notes the Burnham Institute's Steven Frisch.
Apoptosis, or programmed cell death, has become increasingly relevant in an ever-growing number of biomedical fields. This paper, says Steven M. Frisch, assistant staff scientist at the Burnham Institute in La Jolla, Calif., links the fields of integrin signaling with apoptosis in a phenomenon called anoikis.
"Integrins are receptors that bind extracellular matrix proteins to the outside of the cell," explains Frisch. "The extracellular matrix is responsible for tissue organization all over the body. It's also becoming clear that the matrix proteins...