Edited by: Thomas W. Durso Comments by Hailing Hsu, Amgen Inc., Thousand Oaks, Calif.
H. Hsu, J. Xiong, D.V. Goeddel, "The TNF receptor 1-associated protein TRADD signals cell death and NF-b activation," Cell, 81:495-504, 1995. (Cited in more than 150 publications as of April 1997)
Tumor necrosis factor (TNF) is an immunoregulatory cytokine whose activities are signaled main through a cell surface receptor called TNF receptor 1 (TNFR1). Abnormal regulation of TNF has been implicated in inflammatory diseases, such as rheumatoid arthritis.
In this paper, a team of researchers from Tularik Inc., a biotechnology company in South San Francisco, Calif., examined how TNFR1 regulates TNF activities. Hailing Hsu then was a postdoc at Tularik and currently is a research scientist at Amgen Inc. of Thousand Oaks, Calif. She says that TNF, upon binding to TNFR1 on the cell surface, engages in cell death and activation of NF-b, a...