Chemistry

D.F. Hunt, R.A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A.L. Cox, E. Appella, V.H. Engelhard, "Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry," Science, 255:1261- 3, 1992. D.F. Hunt, H. Michel, T.A. Dickinson, J. Sha-banowitz, A.L. Cox, K. Sakaguchi, E. Appella, H.M. Grey, A. Sette, "Peptides presented to the immune system by the murine class II major histocompati

The Scientist Staff
Mar 20, 1994
D.F. Hunt, R.A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A.L. Cox, E. Appella, V.H. Engelhard, "Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry," Science, 255:1261- 3, 1992.

D.F. Hunt, H. Michel, T.A. Dickinson, J. Sha-banowitz, A.L. Cox, K. Sakaguchi, E. Appella, H.M. Grey, A. Sette, "Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad," Science, 256:1817-20, 1992.

Donald F. Hunt (Departments of Chemistry and Pathology, University of Virginia, Charlottesville): "A complex mixture containing more than 10,000 peptide fragments derived from cellular proteins is displayed on the cell surface in association with molecules of the major histocompatibility complex (MHC), class I glycoproteins. Cytotoxic T lymphocytes (CTL) bind to class I molecules, sample the peptides being presented, and lyse those cells that display unusual fragments derived from viruses or tumors.

"In a second stage of the...

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