D.F. Hunt, R.A. Henderson, J. Shabanowitz, K. Sakaguchi, H. Michel, N. Sevilir, A.L. Cox, E. Appella, V.H. Engelhard, "Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry," Science, 255:1261- 3, 1992.

D.F. Hunt, H. Michel, T.A. Dickinson, J. Sha-banowitz, A.L. Cox, K. Sakaguchi, E. Appella, H.M. Grey, A. Sette, "Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad," Science, 256:1817-20, 1992.

Donald F. Hunt (Departments of Chemistry and Pathology, University of Virginia, Charlottesville): "A complex mixture containing more than 10,000 peptide fragments derived from cellular proteins is displayed on the cell surface in association with molecules of the major histocompatibility complex (MHC), class I glycoproteins. Cytotoxic T lymphocytes (CTL) bind to class I molecules, sample the peptides being presented, and lyse those cells that display unusual fragments derived from viruses or tumors.

"In a second stage of the...

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