ADVERTISEMENT
ADVERTISEMENT

Circadian Rhythms

D.P. King, Y.L. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D.L. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek, J.S. Takahashi, "Positional cloning of the mouse circadian Clock gene," Cell, 89:641-53, May 16, 1997. (Cited in more than 160 papers since publication) Comments by Joseph S. Takahashi, a Howard Hughes Medical Institute investigator and professor of neurobiology and physiology at Northwestern University This paper proved to be as significant for

Eugene Russo

D.P. King, Y.L. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D.L. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek, J.S. Takahashi, "Positional cloning of the mouse circadian Clock gene," Cell, 89:641-53, May 16, 1997. (Cited in more than 160 papers since publication)

Comments by Joseph S. Takahashi, a Howard Hughes Medical Institute investigator and professor of neurobiology and physiology at Northwestern University

This paper proved to be as significant for the method researchers employed as for the discovery that resulted from their efforts. By cloning the Clock gene in mice, Northwestern University investigators helped trigger an explosion of findings on the genetics of circadian rhythms--the physiological 24-hour cycles in plants and animals that are regulated both internally and via external cues. By using forward genetics to do so, they helped introduce a new approach to doing genetics in mammals. Researchers typically perform knockout mutations on...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
ADVERTISEMENT