J.L. Cleary et al., "Natural oligomers of the amyloid-β protein specifically disrupt cognitive function," Nat Neurosci, 8:79?84, 2005. (Cited in 124 papers)
James Cleary at the Minneapolis VA Medical Center and colleagues revealed that soluble human forms of amyloid-β oligomer (a-β), a protein implicated in Alzheimer disease, disrupted rats' memory of a learned lever-pressing task. "We didn't see any neurotoxicity, yet we saw cognitive deficits show up shortly after we gave them [the a-β]," Cleary says. The effect went away within just a few hours. "If you tested the animal again a day later, it was able to do the task beautifully," says coauthor Dennis Selkoe.
While previous studies had found cognitive impairments from mixtures of synthetic fibrils, monomers, and oligomers, the effects on cognition of the isolated form of a-β oligomers had never been characterized. "I think it was an important step...
|% Increase in Errors in Lever-Pressing Task|
|Switching Error||Preservation Error|