K. Luger, A.W. Mader, R.K. Richmond, D.F. Sargent, T.J. Richmond, "Crystal structure of the nucleosome core particle at 2.8 Å resolution," Nature, 389:251-60, 1997. (Cited in more than 250 papers since publication)
Comments by Timothy J. Richmond, professor for X-ray crystallography of biological macromolecules at the Institute for Molecular Biology and Biophysics, Swiss Federal Institute of Technology, Zurich
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Pictured is the nucleosome core particle along two axes: Down the DNA superhelix axis (left); perpendicular to the DNA superhelix axis (right). The particle is composed of phosphodiester backbones (brown and turquoise) and eight histone protein main chains (H3 in blue, H4 in green, H2A in yellow, H2B in red).