Edited by: Jennifer Fisher Wilson
Courtesy of John Kuriyan
Comments by Michael J. Eck, assistant professor of biological chemistry and molecular pharmacology, Harvard Medical School, and department of cancer biology, Dana-Farber Cancer Institute
F. Sicheri, I. Moarefi, J. Kuriyan, "Crystal structure of the Src family tyrosine kinase Hck," Nature, 385: 602-9, Feb. 13, 1997. (Cited in more than 160 papers since publication)
Comments by John Kuriyan, professor of molecular biophysics, Howard Hughes Medical Institute, The Rockefeller University
Decades of research have revolved around the Src-family kinases, a closely related group of nonreceptor tyrosine kinases including Src, Hck, and Lck that play a key role in eukaryotic signal transduction. The Src kinases are recognized as important targets for therapeutic interventions to...