For this article, Nadia S. Halim interviewed James Ihle, Howard Hughes Medical Institute investigator and chairman of the department of biochemistry, St. Jude Children's Research Hospital, Memphis, Tenn. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

S. Teglund, C. McKay, E. Schuetz, J.M. van Deursen, D. Stravopodis, D. Wang, M. Brown, S. Bodner, G. Grosveld, and J.N. Ihle, "Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses," Cell, 93:841-50, May 29, 1998. (Cited in more than 175 papers since publication)

The activation of Stat5 proteins had been studied in an incredibly large number of physiological pathways. However, there was confusion about the importance of these proteins until James Ihle, Howard Hughes Medical Institute investigator and chairman of the department of...

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