Edited by: Thomas W. Durso and Karen Young Kreeger
C.U. Kirchgessner, C.K. Patil, J.W. Evans, C.A. Cuomo, L.M. Fried, T. Carter, M.A. Oettinger, J.M. Brown, "DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect," Science, 267:1178-83, 1995. (Cited in more than 140 publications as of February 1997)
Comments by Cordula U. Kirchgessner and J. Martin Brown, department of radiation oncology, Stanford University School of Medicine
A 1995 paper in Cell (T. Blunt et al., Cell, 80:813-23, 1995; discussed in Hot Papers, The Scientist, Jan. 6, 1997, page 15) described an enzyme called DNA-dependent protein kinase (DNA-PK), which catalyzes the repair both of DNA double-strand breaks and of specific DNA breaks occurring in the development of the immune system.
QUICK FIX: Cordula Kirchgessner and Martin Brown presented genetic evidence of an enzyme that catalyzes DNA repair.