Graphic: Courtesy of Shin-Ichiro Imai
Some twenty years ago, Massachusetts Institute of Technology biologist Lenny Guarente began studying aging by timing the lifespan of various yeast strains. Finding one mutant strain that lived about 50% longer than the others, Guarente's team searched the mutant's genome to uncover its secret to long life. The investigation singled out a silent information regulator gene called Sir2, which was expressed at a higher-than-normal rate.
Learning just how Sir2 functions to extend life...
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