Edited by: Karen Young Kreeger
H. Rubbo, R. Radi, M. Trujillo, R. Telleri, B. Kalyanaraman, S. Barnes, M. Kirk, B.A. Freeman, "Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation," Journal of Biological Chemistry, 269:26066-75, 1994. (Cited in more than 70 publications as of August 1996)
Comments by Bruce Freeman, University of Alabama, Birmingham
Understanding the chemical actions of nitric oxide (NO)-- a free radical species that acts as a mediator of signal transduction -- has been a hot topic of research since the late 1980s. Nitric oxide, because of its unpaired electron, is classified as a free radical and displays important reactivities with certain types of proteins and other free radicals.
Researchers first observed nitric oxide's role in mediating blood vessel dilation, the killing of invading pathogens by macrophages, and the normal functioning of platelets and neurotransmission. During these early NO studies, investigators believed the chemical to...