Gene Therapy

Inder Verma L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, D. Trono, "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector," Science, 272:263-7, 1996. (Cited in more than 185 papers since publication) Comments by Inder M. Verma, American Cancer Society professor of molecular biology at the Salk Institute for Biological Studies, La Jolla, Calif. In the world of gene therapy, there's a fine line between friend and foe. HIV at

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Inder Verma
L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, D. Trono, "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector," Science, 272:263-7, 1996. (Cited in more than 185 papers since publication)

Comments by Inder M. Verma, American Cancer Society professor of molecular biology at the Salk Institute for Biological Studies, La Jolla, Calif.

In the world of gene therapy, there's a fine line between friend and foe. HIV attacks cells with unparalleled efficiency. But, with a little genomic tweaking, the deadly virus could become an excellent, safe gene courier that might one day effectively eliminate cancerous cells. The authors of this paper were the first to report the use of a retroviral vector system based on HIV.

Unlike other retroviruses, HIV, which is classified as a lentivirus, can target both dividing and nondividing cells such as...

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