Edited by: Karen Young Kreeger
Exposing Adenoviruses: Inder Verma and colleagues used nude mice to study immune system and humoral responses during gene therapy.
Comments by Inder M. Verma, Salk Institute, San Diego
For the last few years, gene therapists have focused their attention on recombinant adenoviruses to deliver genes to cells in vivo. But in several studies, these vectors impart only short-lived expression of the desired therapy. Investigators surmised that the host immune system was responsible for preventing prolonged expression of the foreign genes carried by the adenoviral vectors.
A group led by...