Y.P. Yang, F.A. Nunes, K. Berencsi, E. Gonczol, J.F. Engelhardt, J.M. Wilson, "Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis," Nature Genetics, 7:362-9, 1994. (Cited in more than 75 publications as of April 1996)
Comments by James M. Wilson, University of Pennsylvania
VIRUS BASHER: Penn's James Wilson limits the mouse immune reaction when testing gene therapy for cystic firbrosis. His technique: Cripple the viral vector.
However, about a week after therapy was given and the gene-carrying virus delivered its load,...