K. Nakayama, N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I Hori, D.Y. Loh, K. Nakayama, "Mice lacking p27 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors," Cell, 85:707-20, 1996. (Cited in more than 155 papers since publication)
Comments by Kei-ichi Nakayama, a professor of molecular and cellular biology at Kyushu University, Fukuoka, Japan
Cells proliferate. Cells differentiate. Cells also occasionally stop and take a break from all of that activity. How they get from point A to point B, and how they decide when to take a breather (referred to in technical circles as cell-cycle arrest), is a subject of intense research.
"There has been remarkable progress regarding p27 status and cancer."