Edited by: Neeraja Sankaran
D.A. Geller, C.J. Lowenstein, R.A. Shapiro, A.K. Nussler, M. Di Silvio, S.C. Wang, D.K. Nakayama, R.L. Simmons, S.H. Snyder, T.R. Billiar, "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes," Proceedings of the National Academy of Sciences, 90:3491-5, 1993. (Cited in 135 publications through March 1995)
GROUNDWORK: Cloning the human gene for iNOS opens up avenues of therapy for a variety of diseases, says David Geller
According to David A. Geller, a research assistant professor of surgery at the University of Pittsburgh School of Medicine, the cloning and expression of the gene described in this paper has garnered attention from the scientific community because of the biological importance of its product.
The protein--an inducible form of nitric oxide synthase (iNOS)--is responsible for the generation of nitric oxide (NO) from arginine. "NO mediates...