Hot Papers

M.H. Siegelman, M. van de Rijn, I.L. Weissman, "Mouse lymph node homing receptors cDNA clone encodes a glycoprotein revealing tandem interaction domains," Science, 243, 1165-72, 3 March 1989. Mark Siegelman (Stanford University Medical Center, Calif.): "Our characterization of the lymph node-specific homing receptor protein showed it to be composed of a core protein with complex and novel posttrans- lational modifications. Our cloning of the cDNA encoding the core polypeptide revealed an entir

The Scientist Staff
May 27, 1990

M.H. Siegelman, M. van de Rijn, I.L. Weissman, "Mouse lymph node homing receptors cDNA clone encodes a glycoprotein revealing tandem interaction domains," Science, 243, 1165-72, 3 March 1989.

Mark Siegelman (Stanford University Medical Center, Calif.): "Our characterization of the lymph node-specific homing receptor protein showed it to be composed of a core protein with complex and novel posttrans- lational modifications. Our cloning of the cDNA encoding the core polypeptide revealed an entirely new class of adhesion molecule with a remarkable protein design. This design consists of a tandem array of three independent protein domains brought together to form the homing receptor protein. These domains are a lectin domain, an epidermal growth factor-like domain, and two similar repeats of a motif present in a number of proteins that regulate the complement cascade. The unique juxtaposition of these protein segments recruited into a single molecule provides a rich model for...

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