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S.J. Tapscott, R.L. Davis, M.J. Thayer, P.-F. Cheng, et al., "MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts," Science, 242, 405-11, 21 October 1988. Stephen Tapscott (Fred Hutchinson Cancer Research Center, Seattle): "This article reported our initial effort to characterize the MyoD protein. The two major points of the article are: (1) MyoD is a phosphorylated nuclear protein present in myoblasts and myotubes; and (2) The previously recogniz

The Scientist Staff
May 13, 1990

S.J. Tapscott, R.L. Davis, M.J. Thayer, P.-F. Cheng, et al., "MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts," Science, 242, 405-11, 21 October 1988.

Stephen Tapscott (Fred Hutchinson Cancer Research Center, Seattle): "This article reported our initial effort to characterize the MyoD protein. The two major points of the article are: (1) MyoD is a phosphorylated nuclear protein present in myoblasts and myotubes; and (2) The previously recognized region of similarity between MyoD and Myc is both necessary and sufficient for the ability of MyoD to activate the myogenic program. It has now become evident that MyoD is a member of a potentially very large family of proteins that share this region of similarity, which has been referred to as a helix-loop-helix motif. Many of these related proteins have been identified by sequence homology, and their role in differentiation of various lineages...

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