W.E. Wright, D.S. Sassoon, V.K. Lin, "Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD," Cell, 56, 607-17, 24 February 1989.
Woodring E. Wright (University of Texas Southwestern Medical Center, Dallas): "This paper describes the use of a novel cell line that overexpresses regulatory factors for the identification, cloning, and initial characterization of myogenin, a protein that regulates the decision of muscle cells to differentiate. Trans- fection of a myogenin cDNA into C3H10T1/2 fibroblastoid stem cells causes their conversion into muscle cells. The discovery that myogenin shared a region of the myc homology domain with the muscle regulatory factor MyoD1 established that there was a family of related proteins controlling myogenesis. Simultaneously with our work, other investigators used the myc homology domain to independently clone myogenin and additional family members.
Although invertebrate systems have dominated the study of morphogenesis, the discovery of the myogenin family of...
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