Hot Papers

T.R. Cech, "Conserved sequences and structures of group I introns: building an active site for RNA catalysis - a review," Gene, 73, 259-71, 20 December 1988. Thomas R. Cech (University of Colorado, Boulder): "How to look good writing a review article: Pick some really brilliant work to write about. In this case, the difficult and very successful head-scratching that provided the basis for the review was done by Francois Michel and, independently, by Richard Waring and Wayne Davies in 1982. Bas

The Scientist Staff
Apr 1, 1990

T.R. Cech, "Conserved sequences and structures of group I introns: building an active site for RNA catalysis - a review," Gene, 73, 259-71, 20 December 1988.

Thomas R. Cech (University of Colorado, Boulder): "How to look good writing a review article: Pick some really brilliant work to write about. In this case, the difficult and very successful head-scratching that provided the basis for the review was done by Francois Michel and, independently, by Richard Waring and Wayne Davies in 1982. Based on just a handful of nucleotide sequences of fungal mitochondrial introns, they were able to decipher the secondary structure into which these RNA molecules fold. The RNA structures became exciting to a much larger audience when their function was uncovered: They define a class of self-splicing RNA molecules.

"One of my main goals in the review was to update the compilation of this group of introns. The...

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