W.W. Lamph, P. Wamsley, P. Sassone-Corsi, I.M. Verma, "Induction of proto-oncogene JUN/AP-1 by serum and TPA," Nature, 334 (6183), 629-31, 18 August 1988.
William W. Lamph (Molecular Biology and Virology Laboratory, Salk Institute, La Jolla, Calif.): "This paper demonstrates that routine proto-oncogene jun is inducible in NIH 3T3 cells with serum or TPA and, hence, like proto-oncogene fos, belongs to the immediate early family of genes. The coordinate expression of these genes, fos and jun, is consistent with the observation that the Jun protein is the Fos-associated protein P39 and that Fos and Jun proteins form a complex that transactivates transcription from TRE-containing promoters.
"Therefore, this paper provides a link between incoming signals from extracellular stimuli and the activation of a network of genes (including fos and jun) whose gene products are able to transactivate secondary genes in response to the stimulus."
M. Ptashne, "How eukaryotic transcriptional activators work,"...