IAP: Antagonizing the Antagonist

For this article, Laura DeFrancesco interviewed David Vaux, principal research fellow, Walter and Eliza Hall Institute, Melbourne, Australia. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. A.M. Verhagen et al., "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins," Cell, 102: 43-53, July 7, 2000. (Cited in 176 papers) Apoptosis, or programmed c

Laura Defrancesco
Mar 3, 2002
For this article, Laura DeFrancesco interviewed David Vaux, principal research fellow, Walter and Eliza Hall Institute, Melbourne, Australia. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

A.M. Verhagen et al., "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins," Cell, 102: 43-53, July 7, 2000. (Cited in 176 papers)


Apoptosis, or programmed cell death, provides organisms a way to remove unwanted cells, such as during morphogenesis, or to defend against viral infection. Of course, certain molecules exist to prohibit apoptosis. One of these proteins, aptly named Inhibitor of Apoptosis Protein (IAP), was first found in viruses, which use them to keep host cells alive while the virus replicates and propagates. These IAPs interfere with key effectors of apoptosis, the family of...

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