IKK2 Gene Essential for Liver Development

For this article, Jim Kling interviewed Inder M. Verma, professor of genetics at the Salk Institute for Biological Studies. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more than the average paper of the same type and age. Q.T. Li, D. Van Antwerp, F. Mercurio, K.F. Lee, I.M. Verma, "Severe liver degeneration in mice lacking the I kappa B kinase 2 gene," Science, 284:321-5, April 9, 1999. (Cited in 150 papers) Courtesy of Inder M. VermaInder M.

Jim Kling
Jun 24, 2001
For this article, Jim Kling interviewed Inder M. Verma, professor of genetics at the Salk Institute for Biological Studies. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more than the average paper of the same type and age.

Q.T. Li, D. Van Antwerp, F. Mercurio, K.F. Lee, I.M. Verma, "Severe liver degeneration in mice lacking the I kappa B kinase 2 gene," Science, 284:321-5, April 9, 1999. (Cited in 150 papers)



Courtesy of Inder M. Verma

Inder M. Verma

NF-kB, a central molecule in immune response regulation, growth, and development, switches on many of the genes involved with these vital processes. When inactive, NF-kB resides in the cell cytoplasm and is blocked by IkB proteins (IkBa and IkBa), which prevent it from entering the nucleus. NF-kB is released when...

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