T.L. Walunas, D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J Freeman, J.M. Green, C.B. Thompson, J.A. Bluestone, "CTLA-4 can function as a negative regulator of T-cell activation," Immunity, 1:405-13, 1994. (Cited in more than 40 publications as of February 1996)
Comments by Jeffrey A. Bluestone, University of Chicago, and Craig B. Thompson, Howard Hughes Medical Institute, University of Chicago
TURN-OFF:Jeffrey Bluestone hopes to understand how the immune system shuts itself down.
"CTLA-4 was of interest because it was a homolog-a gene with the same structure, chromosomal location, ligands-of a molecule called CD28," explains Craig B. Thompson, a professor of medicine and a Howard Hughes Medical Institute investigator at the University of Chicago.