Edited by Neeraja Sankaran
K.L. Rock, C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, A.L. Goldberg, "Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules," Cell, 78:761-71, 1994. (Cited in nearly 70 publications through November 1995) Comments by Kenneth Rock, Dana-Farber Cancer Institute, Boston
This paper discusses the biochemistry of the cellular processes that allow the immune system to recognize various peptides-pieces of protein-present on the surfaces of different cells.
ON THE SURFACE: Dana-Farber Cancer Institute's Kenneth Rock and his colleagues determined how MHC-associated peptides are generated.
Kenneth Rock, an associate professor of pathology in the division of lymphocyte biology at the Dana-Farber Cancer Institute and Harvard Medical School, explains that "all cells display peptides from their expressed genes in combination with special membrane-bound proteins of the major histocompatibility complex...