Edited by: Neeraja D. Sankaran
R.M. Chicz, R.G. Urban, J.C. Gorga, D.A.A. Vignali, W.S. Lane, J.L. Strominger, "Specificity and promiscuity among naturally processed peptides bound to HLA-Dr alleles," Journal of Experimental Medicine, 178:27-47, 1993. (Cited in 107 publications through January 1995)
Comments by Roman M. Chicz,department of molecular and cellular biology, Harvard University
One of the most important findings in this article, according to its authors, was the observation of promiscuous self peptides. Roman Chicz, a staff scientist in the department of molecular and cellular biology at Harvard University, explains that "these are naturally processed peptides generated by different cell lines, which display the unusual characteristic of high-affinity binding to multiple human class II major histocompatibility complex [MHC] molecules." MHC molecules are unique tags located on the surface of an individual's cells that help that person's immune system recognize itself. Any substance without MHC molecules is recognized as...