Immunology

E.J. Ziegler, C.J. Fisher, C.L. Sprung, R.C. Straube, et al., "Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin," New England Journal of Medicine, 324:429-36, 1991. Charles J. Fisher (Center for Critical Care Research, University Hospitals of Cleveland): "Sepsis syndrome is a complex clinical problem resulting from overwhelming infection leading to septic shock and death. The incidence of sepsis syndrome increased 139 percent in the

The Scientist Staff
May 24, 1992

E.J. Ziegler, C.J. Fisher, C.L. Sprung, R.C. Straube, et al., "Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin," New England Journal of Medicine, 324:429-36, 1991.

Charles J. Fisher (Center for Critical Care Research, University Hospitals of Cleveland): "Sepsis syndrome is a complex clinical problem resulting from overwhelming infection leading to septic shock and death. The incidence of sepsis syndrome increased 139 percent in the 10-year period ending in 1987 and has an average mortality of 40 percent. Endotoxin secreted by gram-negative bacteria commonly precipitates sepsis syndrome and septic shock by stimulating the macrophage and monocyte to secrete cytokines such as tumor necrosis factor, interleukin-1, interleukin-6, interleukin-8, as well as other mediators of the inflammatory cascade. These endogenous mediators then precipitate cardiovascular insufficiency, multi-organ dysfunction syndrome, cardiovascular collapse, and death.

"Our paper is an important milestone in the field of immunotherapy of sepsis syndrome. This...

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