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R.J. Deshaies B.D. Koch, M. Werner-Washburne, E.A. Craig, R. Schekman, "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides, Nature, 332 (6167), 800-805, 28 April 1988. Raymond Deshaies (Department of Biochemistry, University of California, Berkeley): "A primary reason that this is an important paper is that much biochemical work had been done on hsp70s, but very little was known about what physiological role they might play in the ce

The Scientist Staff

R.J. Deshaies B.D. Koch, M. Werner-Washburne, E.A. Craig, R. Schekman, "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides, Nature, 332 (6167), 800-805, 28 April 1988.

Raymond Deshaies (Department of Biochemistry, University of California, Berkeley): "A primary reason that this is an important paper is that much biochemical work had been done on hsp70s, but very little was known about what physiological role they might play in the cell. A few years ago, some work suggested that in a test tube these proteins participated in a certain reaction, but the studies never showed that the protein was able to do it within a cell. That's the important link that we've added and that we've reported on here. It makes the conclusion more compelling by having two entirely different independent approaches and two different labs arrive at the same results. It was one of those...

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