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Mapping methylation

Credit: © Cell Press" /> Credit: © Cell Press The paper: X. Zhang et al., "Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis," Cell, 126:1189-201, 2006. (Cited in 94 papers) The finding: The researchers created a Web tool to view the DNA methylation and gene expression data. "It's extremely useful,"

Elie Dolgin
<figcaption> Credit: © Cell Press</figcaption>
Credit: © Cell Press

The paper:

X. Zhang et al., "Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis," Cell, 126:1189-201, 2006. (Cited in 94 papers)

The finding:

The researchers created a Web tool to view the DNA methylation and gene expression data. "It's extremely useful," says Jerzy Paszkowski of the University of Geneva, who last year used the Web tool to show that methylation controls inheritance of epigenetic information (Cell, 130:851-62, 2007).

The follow up:

The initial DNA methylation map had a resolution of only 35 bp. Earlier this year, both Jacobsen's and Ecker's teams separately used new sequencing techniques to develop new methylome maps with single-base resolution. "Now with sequencing you can see the absolute context of where methylation takes place," says Ecker.

The next step:

Both the 2006 and 2008 methylomes provide only "snapshots" of average DNA methylation across the whole...

Methylation changes in mutant plants compared to wild types:
Mutants lacking only non-CG methylation: 7% less
Mutants lacking both CG and non-CG methylation: 64% less

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