R.M. Bertina, B.P.C. Koeleman, T. Koster, F.R. Rosendaal, R.J. Dirven, H. de Ronde, P.A. van der Velden, P.H. Reitsma, "Mutation in blood coagulation factor V associated with resistance to activated protein C," Nature, 369:64-7, 1994. (Cited in more than 100 publications through September 1995) Comments by Rogier Bertina, University Hospital of Leiden, Netherlands
According to Rogier Bertina, a professor of hematology at the University Hospital of Leiden in the Netherlands, this paper "provides the molecular [genetic] basis for APC resistance, a phenotype frequently observed in patients who have a tendency to develop venous thrombosis -- blood clots in their veins."
Bertina explains that "APC-activated protein C-is an important anticoagulant substance in the blood. Previously, it was shown that the anticoagulant effects of this protein were not fully seen in cases of APC resistance" (B. Dahlbck et al., Proceedings of the National Academy of Sciences, 90:1004-8, 1993)....
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