Microscopy

M. Radmacher, R.W. Tillmann, H.E. Gaub, "Imaging viscoelasticity by force modulation with the atomic force microscope," Biophysical Journal, 64:735-42, 1993. (Cited in22 publications through December 1994) Comments by Manfred Radmacher,University of California, Santa Barbara The development of such high-resolution visualization instruments as the atomic force microscope (AFM) has played an important role in the study of cellular and macromolecular structures, notes biophysicist Manfred Radmac

Neeraja Sankaran
Feb 19, 1995
M. Radmacher, R.W. Tillmann, H.E. Gaub, "Imaging viscoelasticity by force modulation with the atomic force microscope," Biophysical Journal, 64:735-42, 1993. (Cited in22 publications through December 1994)

Comments by Manfred Radmacher,University of California, Santa Barbara

The development of such high-resolution visualization instruments as the atomic force microscope (AFM) has played an important role in the study of cellular and macromolecular structures, notes biophysicist Manfred Radmacher, currently a postdoctoral scientist in the physics department at the University of California, Santa Barbara.

With resolution capabilities comparable to those of electron microscopes, the AFM--which gives information on surface topography of a sample--can be operated in native environments without the need for fixing samples, he explains. In this paper, the authors have described a technique called force modulation and extended the applications of the AFM to incorporate information on elasticity.

"Besides looking at the shape of a surface, we can now find out the...

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