Molecular Biology

p.17 A.A. Levin, L.J. Sturzenbecker, S. Kazmer, T. Bosakowski, C. Huselton, G. Allenby, J. Speck, C. Kratzeisen, M. Rosenberger, A. Lovey, J.F. Grippo, "9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa," Nature, 355:359-61, 1992. Arthur A. Levin and Joseph F. Grippo (Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, N.J.): "The biologic activities of the all-trans (t) isomer of retinoic acid (RA) are mediated through the binding and activati

The Scientist Staff
Nov 14, 1993

p.17

A.A. Levin, L.J. Sturzenbecker, S. Kazmer, T. Bosakowski, C. Huselton, G. Allenby, J. Speck, C. Kratzeisen, M. Rosenberger, A. Lovey, J.F. Grippo, "9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa," Nature, 355:359-61, 1992.

Arthur A. Levin and Joseph F. Grippo (Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, N.J.): "The biologic activities of the all-trans (t) isomer of retinoic acid (RA) are mediated through the binding and activation of a family of nuclear RA receptors (RARs) that are members of the steroid/thyroid superfamily of ligand- dependent transcription factors. A second family of nuclear RA receptors, the RXRs, was discovered that were weakly activated by t-RA but did not directly bind this ligand (D.J. Mangelsdorf, et al., Nature, 345:224-9, 1990 and Hot Papers, The Scientist, Nov. 25, 1991, page 16). These results suggested that a t-RA metabolite was the proximate ligand for the RXRs, and we...

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