Molecular Biology

T.J. Schall, M. Lewis, K.J. Koller, A. Lee, G.C. Rice, G.H.W. Wong, T. Gatanoga, et al., "Molecular cloning and expression of a receptor for human tumor necrosis factor," Cell, 61:361-70, 1990. Thomas Schall (Genentech Inc., South San Francisco, Calif.): "The biological effects of the protein known as tumor necrosis factor (TNF) have puzzled inves- tigators for years. Though binding studies have revealed that virtually all mammalian cells possess TNF receptors, the molecule's biological activit

The Scientist Staff
Mar 15, 1992

T.J. Schall, M. Lewis, K.J. Koller, A. Lee, G.C. Rice, G.H.W. Wong, T. Gatanoga, et al., "Molecular cloning and expression of a receptor for human tumor necrosis factor," Cell, 61:361-70, 1990.

Thomas Schall (Genentech Inc., South San Francisco, Calif.): "The biological effects of the protein known as tumor necrosis factor (TNF) have puzzled inves- tigators for years. Though binding studies have revealed that virtually all mammalian cells possess TNF receptors, the molecule's biological activities are somewhat paradoxical. On some cells, TNF acts as a growth factor, while on other cells--including certain tumor cells--it elicits clear cytotoxic effects.

"Our report on the molecular cloning and characterization of a cell-surface TNF receptor, along with a concomitant report by Hansruedi Loetscher and colleagues at Hoffmann-La Roche Ltd. (Cell, 61:351-59, 1990 [Hot Papers, The Scientist, Nov. 25, 1991, page 16]), for the first time allowed for an investigation of the complexities of TNF action...

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