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Molecular Biology

M.P. Kamps, C. Murre, X.-h. Sun, D. Baltimore, "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in Pre-B ALL," Cell, 60:547- 55, 1990. Mark Kamps (University of California, San Diego): "In man, most chromosomal translocations elicit tumorigenic effects by introducing a strong enhancer adjacent to a normal cellular gene, such as c-MYC, and constitutively activating its expression. Less frequently, a chimeric oncogene forms by the joining of two distinc

The Scientist Staff

M.P. Kamps, C. Murre, X.-h. Sun, D. Baltimore, "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in Pre-B ALL," Cell, 60:547- 55, 1990.

Mark Kamps (University of California, San Diego): "In man, most chromosomal translocations elicit tumorigenic effects by introducing a strong enhancer adjacent to a normal cellular gene, such as c-MYC, and constitutively activating its expression. Less frequently, a chimeric oncogene forms by the joining of two distinct genes within their coding sequences, ultimately producing a fusion protein in which critical regulatory functions are altered or deleted.

"This paper describes the molecular result of the t(1;19) chromosomal translocation, which combines both of these oncogenic mechanisms, inducing the expression of the normally silent PBX1 homeobox gene in pre-B cells by appending its 3e homeobox encoding sequences to the 5e transactivator encoding sequences of the E2A gene. The implication that both the transactivation domain of...

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