Molecular Biology

B. Mosley, M.P. Beckmann, C.J. March, R.L. Idzerda, S.D. Gimpel, T. VandenBos, D. Friend, A. Alpert, D. Anderson, J. Jackson, J.M. Wignall, C. Smith, B. Gallis, J.E. Sims, D. Urdal, M.B. Widmer, D. Cosman, L.S. Park, "The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms," Cell, 59, 335-48, 20 October 1989. David Cosman (Immunex Corp., Seattle): "I can think of several reasons why our paper has been cited. There is substantial interest i

The Scientist Staff
Jan 6, 1991

B. Mosley, M.P. Beckmann, C.J. March, R.L. Idzerda, S.D. Gimpel, T. VandenBos, D. Friend, A. Alpert, D. Anderson, J. Jackson, J.M. Wignall, C. Smith, B. Gallis, J.E. Sims, D. Urdal, M.B. Widmer, D. Cosman, L.S. Park, "The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms," Cell, 59, 335-48, 20 October 1989.

David Cosman (Immunex Corp., Seattle): "I can think of several reasons why our paper has been cited. There is substantial interest in the pleiotropic biological activities of interleukin 4 (IL-4), and the molecular cloning of the IL-4 receptor provides a necessary first step toward understanding how IL-4 transduces so many different signals in different cell types. The structure of the extracellular, ligand-binding domain of the receptor showed significant homology with other cytokine receptors (IL-2Rb, erythropoietin, IL-6), and we and others have since extended this observation to define an extensive new family of cytokine receptors....

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