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Molecular Biology

L. Osborn, C. Hession, R. Tizard, C. Vassallo, et al., "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes," Cell, 59, 1203-11, 22 December 1989. Laurelee Osborn (Biogen Inc., Cambridge, Mass.): "Vascular cell adhesion molecule 1 (VCAM1) is of interest to scientists in several disciplines, particularly those studying cell-cell adhesion mechanism and the mechanisms by which the inflammatory response begins and progre

The Scientist Staff

L. Osborn, C. Hession, R. Tizard, C. Vassallo, et al., "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes," Cell, 59, 1203-11, 22 December 1989.

Laurelee Osborn (Biogen Inc., Cambridge, Mass.): "Vascular cell adhesion molecule 1 (VCAM1) is of interest to scientists in several disciplines, particularly those studying cell-cell adhesion mechanism and the mechanisms by which the inflammatory response begins and progresses. VCAM1 binds lymphocytes and monocytes and is induced by the inflammatory cytokines interleukin 1 and tumor necrosis factor a on the surface of endothelial cells. Therefore, VCAM1 has potential relevance to the normal operation of the immune response as well as to a large group of diseases in which vascular and other tissues are damaged by adhering and infiltrating mononuclear cells.

"This paper also describes a novel method of screening for cDNAs of adhesion molecules. This technique involves a direct...

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