J. Johnson et al., "Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood," Cell, 122:303-15, 2005. (Cited in 81 papers)
Jonathan Tilly, director of the Vincent center for reproductive biology at Massachusetts General Hospital, and colleagues showed in 2005 that mice sterilized by chemotherapy or lacking a key gene for making oocytes could be prompted to develop immature oocytes after bone marrow transplantation.
Subsequent studies appeared suggesting that bone marrow stem cells couldn't possibly produce mature fertilizable eggs, and Tilly had to counter claims that he overinterpreted results.
The new finding:
Now, an in-press study in the Journal of Clinical Oncology reveals that in a mouse model of chemotherapy-induced ovarian failure, bone marrow transplant restored fertility. But, the offspring are not derived from donor stem cells.
|In adult murine bone marrow, Tilly's group found mRNA expression for the following germline markers.|
|Oct 4, Mvh, Dazl, Stella, Fragilis, Nobox|