Edited by: Neeraja Sankaran
A.S. Weyrich, X.L. Ma, D.J. Lefer, K.H. Albertine, A.M. Lefer, "In vivo neutralization of P-selectinprotects feline heart andendothelium in myocardialischemia and reperfusion injury," Journal of Clinical Investigation, 91:2620-29, 1993. (Cited in 53publications through February 1995)
Comments by Allan M. Lefer,Thomas Jefferson University
GAINS ON THE HEART FRONT: Allan Lefer's team has shown that neutralizing the glycoprotein P-selectin can confer protection against injury to the heart cells and hence, heart attacks in cats.
Normally present in platelets, leukocytes, and endothelial cells, the selectins play a role in cellular communication and movement. Lefer, chairman of the physiology department at Jefferson and a professor in the department, explains that these glycoproteins...