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Researchers Are Getting Specific About Protein Kinase Inhibitors

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. S.P. Davies et al., "Specificity and mechanism of action of some commonly used protein kinase inhibitors," Biochemical Journal, 351:95-105, Oct. 1, 2000. (Cited in 191 papers) In signal transduction research, protein kinase inhibitors help scientists tease out the vagaries of complex signa

Jeffrey Perkel
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

S.P. Davies et al., "Specificity and mechanism of action of some commonly used protein kinase inhibitors," Biochemical Journal, 351:95-105, Oct. 1, 2000. (Cited in 191 papers)

In signal transduction research, protein kinase inhibitors help scientists tease out the vagaries of complex signaling pathways, but anecdotal evidence suggests that they are flawed tools at best, lacking the specificity necessary to draw conclusions from their use. Though experts agree that inhibitors have a legitimate place in science as screening tools, can researchers conduct good science on the carbon backbones of such agents?

Philip Cohen decided to find out. Cohen, Royal Society research professor and director of the Medical Research Council's protein phosphorylation unit, University...

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