Researchers Dissect the Mechanisms of HIV Infection

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. For all that is known about human immunodeficiency virus (HIV), some remarkably fundamental questions remain. One of the most notable, perhaps, is just how HIV manages to infect its primary target, CD4+-T cells, when so few of those cells can be found at the virus' typical entry points: the v

Jeffrey Perkel
May 26, 2002
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

For all that is known about human immunodeficiency virus (HIV), some remarkably fundamental questions remain. One of the most notable, perhaps, is just how HIV manages to infect its primary target, CD4+-T cells, when so few of those cells can be found at the virus' typical entry points: the vagina, uterus, cervix, and rectum. It is conceivable that the virus may happen upon a stray macrophage or T cell, but for the most part, these cells are hard to come by.


Courtesy of Yvette van Kooyk

Yvette van Kooyk

Two years ago, Yvette van Kooyk, professor of molecular cell biology at Vrije University Medical Center, Amsterdam, and postdoc Teunis Geijtenbeek published...