Signal Transduction

M. Muzio, A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, V.M. Dixit, "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex," Cell, 85:817-27, 1996. (Cited more than 420 times since publication) Comments by Vishva M. Dixit, Director of Molecular Oncology, Genentech Inc., South San Francisco, Calif. OPENING DOORS: A tech

The Scientist Staff
May 24, 1998

M. Muzio, A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, V.M. Dixit, "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex," Cell, 85:817-27, 1996. (Cited more than 420 times since publication)

Comments by Vishva M. Dixit, Director of Molecular Oncology, Genentech Inc., South San Francisco, Calif.


OPENING DOORS: A technique Genentech's Vishva Dixit and colleagues used to identify parts of the cell-death signaling complex has since aided research in other fields.

Some components of the cell's intricate death effector machinery have eluded discovery. Characterizing these signaling complexes has been a major goal for researchers studying signal transduction. But many of these signaling proteins are simply present in quantities too small to be subjected to protein sequence analysis. Earlier analytical methods either failed to...

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