Signal Transduction

Edited by: Paul Smaglik H. Duan, A.M. Chinnaiyan, P.L. Hudson, J.P. Wing, W. He, V.M. Dixit, "ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein ced-3, is activated during Fas- and tumor necrosis factor-induced apoptosis," Journal of Biological Chemistry, 271:1621-5, 1996. (Cited in more than 125 publications since its publication in January 1996)Comments by Vishva M. Dixit, Director of Molecular Oncology, Genentech Inc., South San Francisco, Calif. THE EXE

Paul Smaglik
Feb 15, 1998

Edited by: Paul Smaglik
H. Duan, A.M. Chinnaiyan, P.L. Hudson, J.P. Wing, W. He, V.M. Dixit, "ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein ced-3, is activated during Fas- and tumor necrosis factor-induced apoptosis," Journal of Biological Chemistry, 271:1621-5, 1996. (Cited in more than 125 publications since its publication in January 1996)Comments by Vishva M. Dixit, Director of Molecular Oncology, Genentech Inc., South San Francisco, Calif.


THE EXECUTIONER UNCLOAKED: Genentech's Vishva Dixit identified ICE-LAP3 as the death effector, then used an antibody to pinpoint its location.
Scientists searching for a mammalian genetic trigger for apoptosis turned to a worm for hints. Genetic analysis of the nematode Caenorhabditis elegans revealed three genes that regulate cell death-ced-3, ced-4, and ced-9. Both ced-3 and ced-4 encode proteins required for somatic cell death in the nematode (H.M. Ellis, H.R. Horowitz, Cell, 44:817-29,...

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