Edited by: Paul Smaglik
D.R. Alessi, A. Cuenda, P. Cohen, D.T. Dudley, A.R. Saltiel, "PD098059 is a specific inhibitor of mitogen-activated protein kinase kinase in vitro and in vivo," Journal of Biological Chemistry, 270:27489-94, 1995. (Cited in more than 150 publications through October 1997)
Comments by Alan R. Saltiel, department of signal transduction, Parke-Davis, Ann Arbor, Mich.
The chemical signals triggering cellular growth resemble multiple pathways more closely than a single trail. Consequently, researchers have had difficulty blocking them. In previous work biochemist Alan R. Saltiel, and colleagues at Parke-Davis in Ann Arbor, Mich., searched for-and found- one way (D.T. Dudley et al., Proceedings of the National Academy of Sciences, 92:7686-9, 1995). The researchers tried more than 160,000 molecules before finding one that somehow turned off an enzyme that activates cell growth.
CHEMICAL MAZE: Parke-Davis biochemist Alan Saltiel found a way to block one chemical pathway...