Edited by: Thomas W. Durso
SEEKING STATs: Anne-Marie O’Farrell, left, and Alice Mui of DNAX found STAT5, a protein that responds to the cytokine interleukin-3.
Comments by Alice L.-F. Mui, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, Calif.
Interleukin-3 (IL-3) is a cytokine that regulates hemopoiesis, the formation of blood cells in the body. In this paper, Alice L.-F. Mui, a senior research associate at the DNAX Research Institute of Molecular and Cellular Biology in Palo Alto, Calif., examined what happens after IL-3 binds to its receptor. "I wanted to find out what the next step in the signal-transduction cascade was," she states. "How does receptor activation lead eventually to...