Signal Transduction

Edited by: Thomas W. Durso SEEKING STATs: Anne-Marie O’Farrell, left, and Alice Mui of DNAX found STAT5, a protein that responds to the cytokine interleukin-3. A.L.-F. Mui, H. Wakao, A.-M. O'Farrell, N. Harada, A. Miyajima, "Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs," EMBO Journal, 14:1166-75, 1995. (Cited in more than 110 publications as of April 1997) Comments by Alice L.-F. Mui, DNAX Research Institu

The Scientist Staff
Jun 8, 1997

Edited by: Thomas W. Durso


SEEKING STATs: Anne-Marie O’Farrell, left, and Alice Mui of DNAX found STAT5, a protein that responds to the cytokine interleukin-3.
A.L.-F. Mui, H. Wakao, A.-M. O'Farrell, N. Harada, A. Miyajima, "Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs," EMBO Journal, 14:1166-75, 1995. (Cited in more than 110 publications as of April 1997)

Comments by Alice L.-F. Mui, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, Calif.

Interleukin-3 (IL-3) is a cytokine that regulates hemopoiesis, the formation of blood cells in the body. In this paper, Alice L.-F. Mui, a senior research associate at the DNAX Research Institute of Molecular and Cellular Biology in Palo Alto, Calif., examined what happens after IL-3 binds to its receptor. "I wanted to find out what the next step in the signal-transduction cascade was," she states. "How does receptor activation lead eventually to...

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