Signal Transduction

Edited by: Karen Young Kreeger "Bloody Hot" Field: Because the signaling protein Stat5 has been found to be active in numerous pathways, many researchers are engaged in studying its various roles, says James Ihle. M. Azam, H. Erdjument-Bromage, B.L. Kreider, M. Xia, F. Quelle, R. Basu, C. Saris, P. Tempst, J.N. Ihle, C. Schindler, "Interleukin-3 signals through multiple isoforms of Stat5," EMBO Journal, 14:1402-11, 1995. (Cited in nearly 70 publications as of December 1996) Comments by James N

The Scientist Staff
Feb 16, 1997

Edited by: Karen Young Kreeger


"Bloody Hot" Field: Because the signaling protein Stat5 has been found to be active in numerous pathways, many researchers are engaged in studying its various roles, says James Ihle.
M. Azam, H. Erdjument-Bromage, B.L. Kreider, M. Xia, F. Quelle, R. Basu, C. Saris, P. Tempst, J.N. Ihle, C. Schindler, "Interleukin-3 signals through multiple isoforms of Stat5," EMBO Journal, 14:1402-11, 1995. (Cited in nearly 70 publications as of December 1996)

Comments by James N. Ihle, St. Jude Children's Research Hospital, Memphis, Tenn.

This paper describes one important piece of the overall picture of how cytokines orchestrate the immune response. "Four years ago, people had cloned many receptors for cytokines," says senior author James N. Ihle, chairman of the biochemistry department at St. Jude Children's Research Hospital in Memphis, Tenn. "What became obvious was that all of these cytokines used structurally related receptors and...

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