Spectroscopy

D. Marion, M. Ikura, R. Tschudin, A. Bax, "Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins," Journal of Magnetic Resonance, 85, 393-9, November 1989.

Ad Bax (National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md.): "In the past decade, two-dimensional nuclear magnetic resonance (NMR) spectroscopy has proved to be an extremely powerful tool for obtaining detailed information on the structure and dynamics of both organic molecules and macro- molecules, such as small proteins and nucleic acids. It was generally believed that recording such spectra required a substantial amount of measuring time--even for concentrated samples--because the entire two-dimensional experiment must be repeated many times in a process known as phase cycling in order to suppress unwanted artifacts. We showed that for many experiments, phase cycling can be omitted and high quality two-dimensional spectra can be...