Edited by : Neeraja Sankaran
Y. Cho, S. Gorina, P.D. Jeffrey, N.P. Pavletich, "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations," Science, 265:346-55, 1994. (Cited in more than 140 publications through November 1995)
Comments by Nikola Pavletich, Memorial Sloan-Kettering Cancer Center, New York City
"One of the goals in cancer biology has been to find a unifying theme underlying the cause of cancer, and the p53 tumor suppressor is the closest we have come to that," declares Nikola Pavletich, an assistant member in the cellular biochemistry and biophysics program at Memorial Sloan-Kettering Cancer Center in New York.
"Because it is the most frequently mutated gene to be identified in triggering many different human cancers, p53 has been the focus of intense research. This paper is the first description of the three-dimensional atomic structure of p53 bound to a DNA molecule," he adds, proposing this as...